Davis Stanley S
Institute of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Vaccine. 2006 Apr 12;24 Suppl 2:S2-7-10. doi: 10.1016/j.vaccine.2005.01.102.
It is important when developing new vaccine systems to give proper attention to the question of delivery. In some cases the judicious choice of a delivery system can provide a greatly enhanced immune response and avoid the need to use a vaccine adjuvant. Delivery systems that have been developed originally for the administration of challenging drug can be used with success for vaccines. Polymer microspheres and lamellar particle based on the biodegradable materials polylactide and polylactide co-glycolide can be employed for the improved parenteral and mucosal administration of antigens. Likewise soluble biopolymers such as chitosan can be used for the improved nasal delivery of various antigens as well as DNA. Results from animal studies and recent clinical trials are provided.
在开发新的疫苗系统时，适当关注给药问题很重要。在某些情况下，明智地选择给药系统可以大大增强免疫反应，并避免使用疫苗佐剂的必要性。最初为给药具有挑战性的药物而开发的给药系统可以成功地用于疫苗。基于可生物降解材料聚乳酸和聚乳酸-乙醇酸共聚物的聚合物微球和层状颗粒可用于改善抗原的肠胃外和粘膜给药。同样，诸如壳聚糖之类的可溶性生物聚合物可用于改善各种抗原以及DNA的鼻腔给药。文中提供了动物研究和近期临床试验的结果。
