Chapman P T, Haskard D O
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Br Med Bull. 1995 Apr;51(2):296-311. doi: 10.1093/oxfordjournals.bmb.a072962.
The last few years have seen an enormous expansion of knowledge regarding the role of cell surface adhesion molecules in biological processes. This article discusses the contribution that adhesion molecules make to the traffic of leukocytes into and within synovium and to the capacity of leukocytes to perform their specialised functions. Because of their importance in cellular interactions, adhesion molecules represent a major potential target for antiinflammatory therapy in rheumatoid and other inflammatory arthritides.
在过去几年中，关于细胞表面黏附分子在生物过程中的作用的知识有了巨大的扩展。本文讨论了黏附分子在白细胞进入滑膜以及在滑膜内移动过程中的作用，以及白细胞执行其特定功能的能力。由于黏附分子在细胞相互作用中具有重要性，它们是类风湿性关节炎和其他炎性关节炎抗炎治疗的主要潜在靶点。
