Fuggle S V, Koo D D
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, England, UK.
Transplantation. 1998 Mar 27;65(6):763-9. doi: 10.1097/00007890-199803270-00001.
Leukocyte adhesion molecules are critically involved at a number of stages in immune and inflammatory responses, and their importance in the response to a renal allograft has been recognized for some years. They are involved in antigen presentation, in the cascade of events leading to extravasation of leukocytes into the allograft, in the subsequent migration of leukocytes through the extracellular matrix, and in the interactions between effector and target cells. Thus the adhesion molecules are highly attractive targets for therapeutic intervention in organ transplantation. Strategies have been explored to exploit the involvement of adhesion molecules in ischemia/reperfusion injury, allograft rejection, and the induction of immunological tolerance. Furthermore, the expression of a number of adhesion molecules is regulated by cytokines, and elevated levels may be detected both in transplant biopsies and as soluble forms measured in serum and urine. It has been proposed that these changes in levels might provide useful information in the diagnosis of allograft rejection and differentiation from other causes of graft dysfunction.
白细胞黏附分子在免疫和炎症反应的多个阶段起着关键作用，并且它们在同种异体肾移植反应中的重要性已被认识多年。它们参与抗原呈递，参与导致白细胞渗入同种异体移植物的一系列事件，参与白细胞随后通过细胞外基质的迁移，以及参与效应细胞与靶细胞之间的相互作用。因此，黏附分子是器官移植治疗干预的极具吸引力的靶点。人们已经探索了利用黏附分子参与缺血/再灌注损伤、同种异体移植物排斥反应以及诱导免疫耐受的策略。此外，许多黏附分子的表达受细胞因子调节，在移植活检中以及作为血清和尿液中测量的可溶性形式都可检测到其水平升高。有人提出，这些水平变化可能为同种异体移植物排斥反应的诊断以及与其他移植功能障碍原因的鉴别提供有用信息。
