整合素-配体结合。整合素是否利用“MIDAS 接触”来抓住一个天冬氨酸？
Integrin-ligand binding. Do integrins use a 'MIDAS touch' to grasp an Asp?
作者信息
Bergelson J M, Hemler M E
机构信息
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Curr Biol. 1995 Jun 1;5(6):615-7. doi: 10.1016/s0960-9822(95)00124-2.
PMID:7552170
Abstract
Integrins use divalent cations, held within a novel 'MIDAS' motif, for ligand binding. It is proposed that a missing coordination site for the cation is provided by a critical acidic residue in the ligand.
摘要
整合素利用存在于一种新型“MIDAS”基序中的二价阳离子进行配体结合。有人提出，配体中的一个关键酸性残基为阳离子提供了一个缺失的配位位点。
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