Crozes-Bony P, Palazzo E, Meyer O, De Bandt M, Kahn M F
Department of Rheumatology, Bichat Teaching Hospital, Paris, France.
Rev Rhum Engl Ed. 1995 Jun;62(6):439-45.
We report a case of familial multiple myeloma in a father and daughter. The same lambda chain was detectable in both patients. Symptom onset occurred three years earlier in the daughter than in the father. We found 52 previously published cases of familial myeloma, of which only 13 occurred in a parent and child. Given the incidence of myeloma in the general population, the occurrence of several cases in the same family is probably not due to chance. The few available data on karyotypes and oncogenes are discordant. The respective role of genetic factors and environmental factors is discussed.
我们报告了一例父亲和女儿均患家族性多发性骨髓瘤的病例。在两名患者中均检测到相同的λ链。女儿的症状出现时间比父亲早三年。我们发现了52例先前发表的家族性骨髓瘤病例，其中只有13例发生在父母与子女之间。鉴于骨髓瘤在普通人群中的发病率，同一家庭中出现多例病例可能并非偶然。关于核型和癌基因的现有数据很少且不一致。本文讨论了遗传因素和环境因素各自的作用。
