Kann P, Zawalski R, Piepkorn B, Schehler B, Beyer J
III. Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universität, Mainz, Germany.
Exp Clin Endocrinol Diabetes. 1995;103(2):113-8. doi: 10.1055/s-0029-1211338.
In a number of endocrine disorders, typical changes in skin thickness can be observed which make measurement of skin thickness interesting in this field. A newly developed mechanical method for measuring skin thickness is presented. Using a digital measuring screw on the dorsum of the hand with a defined measuring force of 10 newton and a resulting tissue compression of 1500 mm Hg, highly reproducible results were obtained (mean coefficient of variation 2.56%). In 129 women, 37 to 78 years old, body mass index < 30 kg/m2, there was no significant relation between body mass index and skin fold thickness. A negative correlation between skin fold thickness and age (r = 0.37, p < 0.001) was detected. This has been shown for skin by other methods previously and is well known to occur in bone, another tissue whose matrix as well as dermis consists mainly of collagen type I. In 30 subjects, half hypopituitary patients, half healthy subjects (17 women, 13 men; 43.3 +/- 10.5 years old), skin fold thickness measured mechanically and sonographically determined skin thickness correlated with r = 0.46 (p < 0.01). A significant correlation between bone mineral density measured by single photon-absorptiometry at the ultradistal forearm and skin fold thickness measured mechanically was found and skin fold thickness measured mechanically was found (r = 0.36, p < 0.05), whereas this was not the case for sonographically determined skin thickness and bone mineral density (r = 0.13, n.s.). This newly developed method might be useful in clinical studies on endocrine disorders affecting skin (and bone) metabolism and the regulation of collagen type I metabolism in general.
在一些内分泌疾病中，可以观察到皮肤厚度的典型变化，这使得在该领域测量皮肤厚度变得很有意义。本文介绍了一种新开发的测量皮肤厚度的机械方法。使用手部背部的数字测量螺杆，施加10牛顿的规定测量力，产生1500毫米汞柱的组织压缩，获得了高度可重复的结果（平均变异系数为2.56%）。在129名年龄在37至78岁、体重指数<30kg/m²的女性中，体重指数与皮褶厚度之间没有显著关系。检测到皮褶厚度与年龄呈负相关（r = 0.37，p < 0.001）。此前通过其他方法已在皮肤中证明了这一点，并且在骨骼中也众所周知会发生这种情况，骨骼是另一种其基质以及真皮主要由I型胶原蛋白组成的组织。在30名受试者中，一半是垂体功能减退患者，一半是健康受试者（17名女性，13名男性；43.3±10.5岁），机械测量的皮褶厚度与超声测量的皮肤厚度的相关性为r = 0.46（p < 0.01）。发现通过单光子吸收法在尺骨远端测量的骨矿物质密度与机械测量的皮褶厚度之间存在显著相关性（r = 0.36，p < 0.05），而超声测量的皮肤厚度与骨矿物质密度之间则不存在这种情况（r = 0.13，无统计学意义）。这种新开发的方法可能有助于进行关于影响皮肤（和骨骼）代谢以及一般I型胶原蛋白代谢调节的内分泌疾病的临床研究。
