Kalogeromitros D, Katsarou A, Armenaka M, Rigopoulos D, Zapanti M, Stratigos I
Department of Dermatology, University of Athens, A. Sygros Hospital, Greece.
Clin Exp Allergy. 1995 May;25(5):461-6. doi: 10.1111/j.1365-2222.1995.tb01078.x.
The purpose of this study was to examine the possible influence of the phases of the menstrual cycle on dermal reactivity to skin-prick testing. We studied 15 atopic, menstruating women with seasonal rhinoconjunctivitis and/or asthma, with known sensitivity to olive and parietaria (mean age 25.2 years) and 15 non-atopic, healthy, female controls (mean age 24.7 years). Skin-prick tests with histamine, morphine, and in the atopic group with parietaria/and/or olive, were repeated three times during the same menstrual cycle, corresponding to bleeding (day 1-4), midcycle (day 12-16) and the late progesterone phase (day 24-28). None of the patients had received oral antihistamines or exogenous hormones for at least 1 month prior to testing. Results indicate a significant increase in weal-and-flare size to histamine, morphine, and parietaria on days 12-16 of the cycle, corresponding to ovulation and peak oestrogen levels. This was observed in both atopic and non-atopic women. Differences in skin reactivity to histamine and morphine between the groups were not significant. Therefore, in women, the phase of the menstrual cycle is another factor that may influence skin-test results.
本研究的目的是探讨月经周期各阶段对皮肤点刺试验中皮肤反应性的可能影响。我们研究了15名患有季节性鼻结膜炎和/或哮喘的特应性月经女性，她们已知对橄榄和墙草敏感（平均年龄25.2岁），以及15名非特应性、健康的女性对照者（平均年龄24.7岁）。在同一个月经周期内，分别于出血期（第1 - 4天）、周期中期（第12 - 16天）和孕酮后期（第24 - 28天），对组胺、吗啡进行皮肤点刺试验，对特应性组还进行了墙草/和/或橄榄的皮肤点刺试验，每种试验均重复三次。在测试前至少1个月内，所有患者均未服用口服抗组胺药或外源性激素。结果表明，在月经周期的第12 - 16天，对应排卵和雌激素水平峰值时，对组胺、吗啡和墙草的风团及红晕大小显著增加。在特应性和非特应性女性中均观察到这一现象。两组之间对组胺和吗啡的皮肤反应性差异不显著。因此，在女性中，月经周期阶段是另一个可能影响皮肤试验结果的因素。
