Gógl A, Ruzsa C S, Fischer E
Acta Physiol Acad Sci Hung. 1977;49(3-4):201-8.
Plasma concentration, hepatic uptake and biliary excretion of intravenously administered rose bengal was determined in rats pretreated with phenobarbital (50 mg/kg) daily, for four days). After an initial (0--16 min) rapid fall in plasma rose bengal concentration caused by hepatic uptake of the dye, the curves in control and pretreated rats did not differ from each other either after administration of a small (5 mg/kg) or a large (50 mg/kg) dose. Hepatic rose bengal concentration was significantly lower in pretreated animals than in the control group. Since liver weight was higher in the phenobarbital pretreated animals than in the controls, the total amount of rose bengal taken up by the liver did not differ in the two groups. The biliary excretion of low dose (5 mg/kg) rose bengal was significantly higher in phenobarbital pretreated than in the control rats but with doses of 50 mg/kg and 100 mg/kg no difference was observed. These doses of rose bengal diminished the increased bile flow caused by phenobarbital.
对每日用苯巴比妥（50毫克/千克）预处理四天的大鼠，测定静脉注射孟加拉玫瑰红后的血浆浓度、肝脏摄取及胆汁排泄情况。在染料被肝脏摄取导致血浆中孟加拉玫瑰红浓度最初（0 - 16分钟）快速下降后，无论是给予小剂量（5毫克/千克）还是大剂量（50毫克/千克），对照组和预处理组大鼠的曲线均无差异。预处理动物肝脏中孟加拉玫瑰红浓度显著低于对照组。由于苯巴比妥预处理动物的肝脏重量高于对照组，两组肝脏摄取的孟加拉玫瑰红总量并无差异。苯巴比妥预处理大鼠中低剂量（5毫克/千克）孟加拉玫瑰红的胆汁排泄显著高于对照大鼠，但在50毫克/千克和100毫克/千克剂量时未观察到差异。这些剂量的孟加拉玫瑰红减少了苯巴比妥引起的胆汁流量增加。
