Fischer E, Varga F
Acta Physiol Acad Sci Hung. 1979;54(1):89-94.
The distribution of intravenously administered rose bengal (RB) depends on its dose. At a low dose (10 mg/kg), RB can be found almost solely in the liver and plasma. However, at higher doses (from 25 up to 200 mg/kg) the amount of RB found in extra-hepatic tissues gradually increases. In this experiment the hepatic transfer maximum of RB amounted to 146 micrograms/kg/min. By increasing the dose from 10 to 200 mg/kg, the hepatic concentration of RB also approached a maximum (1250 micrograms/g). The storage capacity of the liver, however, did not limit the transfer maximum of RB.
静脉注射孟加拉玫瑰红（RB）的分布取决于其剂量。在低剂量（10毫克/千克）时，RB几乎只存在于肝脏和血浆中。然而，在较高剂量（25至200毫克/千克）时，肝外组织中发现的RB量逐渐增加。在本实验中，RB的肝脏转运最大值为146微克/千克/分钟。通过将剂量从10毫克/千克增加到200毫克/千克，RB的肝脏浓度也接近最大值（1250微克/克）。然而，肝脏的储存能力并未限制RB的转运最大值。
