Gupta P C, Murti P R, Bhonsle R B, Mehta F S, Pindborg J J
Basic Dental Research Unit and WHO Collaborating Centre for Oral Cancer Prevention, Tata Institute of Fundamental Research, Bombay, India.
Oral Dis. 1995 Mar;1(1):54-8. doi: 10.1111/j.1601-0825.1995.tb00158.x.
To study the effect of cessation of tobacco use on the incidence of lichen planus, leukoplakia and other oral mucosal lesions.
A 10-yr cohort study in a rural population of Ernakulam district, Kerala, India.
Some 12,212 tobacco users were interviewed and examined in a baseline survey and re-examined annually for 10 years. At each examination they were exposed to health educational programs to encourage them to quit their tobacco use. The incidence rates were calculated using person-years method among those who stopped their tobacco use and all others.
A total of 77,681 person-years of observation accrued among men and 32,544 among women. Among men 6.5% of these and among women 14.4% were in the stopped category. The incidence of oral lichen planus did not show any consistent association with cessation of tobacco habits (incidence ratio 1.35) but for leukoplakia there was a substantial drop in the incidence after cessation (incidence ratio 0.31). Several other tobacco-associated oral mucosal lesions such as oral lichen planus-like lesion, smoker's palate, preleukoplakia, central papillary atrophy of the tongue and leukoedema showed either zero, or very small incidence, after cessation.
The reported association between tobacco use and lichen planus appears to be indirect but for all other lesions it is direct. The cessation of tobacco use led to a substantial fall in the incidence of leukoplakia and other lesions implying a reduced risk for oral cancer after cessation of tobacco use.
研究戒烟对扁平苔藓、白斑及其他口腔黏膜病变发病率的影响。
在印度喀拉拉邦埃尔讷古勒姆区农村人口中进行的一项为期10年的队列研究。
在基线调查中对约12212名烟草使用者进行了访谈和检查，并在10年中每年进行复查。每次检查时，他们都接受健康教育项目，鼓励他们戒烟。使用人年法计算戒烟者和所有其他人群的发病率。
男性共积累了77681人年的观察数据，女性为32544人年。男性中有6.5%、女性中有14.4%属于戒烟组。口腔扁平苔藓的发病率与戒烟之间未显示出任何一致的关联（发病率比为1.35），但对于白斑，戒烟后发病率大幅下降（发病率比为0.31）。其他几种与烟草相关的口腔黏膜病变，如口腔扁平苔藓样病变、吸烟者腭部病变、白斑前期、舌中央乳头萎缩和白色水肿，在戒烟后的发病率为零或非常低。
报告的烟草使用与扁平苔藓之间的关联似乎是间接的，但对于所有其他病变则是直接的。戒烟导致白斑和其他病变的发病率大幅下降，这意味着戒烟后口腔癌风险降低。
