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Up-regulation of resistance-related proteins in human lung tumors with poor vascularization.

作者信息

Koomägi R, Mattern J, Volm M

机构信息

Department of Radiology and Oncology, Tartu University, Estonia.

出版信息

Carcinogenesis. 1995 Sep;16(9):2129-33. doi: 10.1093/carcin/16.9.2129.

DOI:10.1093/carcin/16.9.2129
PMID:7554065
Abstract

Microvessel density was investigated by immunostaining endothelial cells for factor VIII antigen in 84 non-small cell lung carcinomas and compared with the expression of several resistance-related proteins. Glutathione S-transferase-pi, thymidylate synthase, metallothionein and, with limitations, P-glycoprotein were overexpressed in tumors with poor vascularization.

摘要

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