Noelle R J
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
Clin Immunol Immunopathol. 1995 Sep;76(3 Pt 2):S203-7. doi: 10.1016/s0090-1229(95)90234-1.
The function of CD40 and its ligand (CD40L;gp39) has provided a molecular understanding for cognate interactions and the basis for hyper IgM syndrome. Studies using an antibody that neutralizes gp39 function in vivo have demonstrated that interactions between CD40 and gp39 are essential for primary and secondary thymus-dependent humoral immune responses, as well as for the generation of memory B cells. In addition, gp39 is critical for B cells to upregulate important costimulatory molecules and acquire professional antigen-presenting cell status. If B cells do not receive the gp39 signal, they are rendered tolerogenic for T cells. Finally, gp39-CD40 interactions are important in thymic education since blockade of this interaction interrupts negative selection.
CD40及其配体（CD40L；gp39）的功能为同源相互作用提供了分子层面的理解，也是高IgM综合征的基础。使用在体内中和gp39功能的抗体进行的研究表明，CD40与gp39之间的相互作用对于原发性和继发性胸腺依赖性体液免疫反应以及记忆B细胞的产生至关重要。此外，gp39对于B细胞上调重要的共刺激分子并获得专业抗原呈递细胞状态至关重要。如果B细胞未接收到gp39信号，它们就会对T细胞产生耐受性。最后，gp39-CD40相互作用在胸腺发育过程中很重要，因为阻断这种相互作用会中断阴性选择。
