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牙釉质基质蛋白与成釉细胞生物学

Enamel matrix proteins and ameloblast biology.

作者信息

Deutsch D, Catalano-Sherman J, Dafni L, David S, Palmon A

机构信息

Department of Oral Biology, Hebrew University Hadassah, Faculty of Dental Medicine, Jerusalem, Israel.

出版信息

Connect Tissue Res. 1995;32(1-4):97-107. doi: 10.3109/03008209509013710.

Abstract

The paper reviews the changes in ameloblast ultrastructure, concomitant with the changes in its functions across the major stages of amelogenesis. It describes the mechanisms associated with the major events in biosynthesis and degradation of the major enamel proteins (amelogenins and tuftelin/enamelins) and with the presecretory and postsecretory mechanisms leading to the heterogeneity of these extracellular matrix proteins. The gene structure, chromosomal localization, protein, primary structure and possible function, and the involvement of the different proteins in X-linked (amelogenin) and possibly in autosomally linked (tuftelin) amelogenesis imperfecta, the most common hereditary disease of enamel, are also discussed.

摘要

本文综述了成釉细胞超微结构的变化,及其在釉质形成主要阶段伴随的功能变化。它描述了与主要釉质蛋白(釉原蛋白和牙本质涎蛋白/釉蛋白)生物合成和降解中的主要事件相关的机制,以及导致这些细胞外基质蛋白异质性的分泌前和分泌后机制。还讨论了基因结构、染色体定位、蛋白质、一级结构和可能的功能,以及不同蛋白质在X连锁(釉原蛋白)和可能的常染色体连锁(牙本质涎蛋白)釉质发育不全中的作用,釉质发育不全是最常见的遗传性釉质疾病。

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