Liu M, Zhang J
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Chin Med J (Engl). 1995 Jul;108(7):544-7.
Calcium homeostasis in synaptosomes is altered during aging. The intrasynaptomal free calcium concentration ([Ca2+]i) was determined in 3- and 24-month-old rats treated with or without Rb1 and Rg1. As expected, the [Ca2+]i level increased with age. Treatment with Rbl and Rgl elicited an obvious decrease of [Ca2+]i content, especially in aged rates. In addition, Rb1 and Rgl significantly stimulated the activity of Na+, K+-ATPase while Rbl inhibited the activity of Ca2+, Mg2+-ATPase and calmodulin. In view of the close relationship of [Ca2+]i level with aging, the changes of [Ca2+]i induced by Rbl and Rgl, as shown by our results, might provide an explanation of the mechanisms of their antiaging function.
衰老过程中突触体的钙稳态会发生改变。在用或不用Rb1和Rg1处理的3月龄和24月龄大鼠中测定了突触体内游离钙浓度（[Ca2+]i）。正如预期的那样，[Ca2+]i水平随年龄增长而升高。用Rbl和Rgl处理可使[Ca2+]i含量明显降低，尤其是在老年大鼠中。此外，Rb1和Rgl显著刺激Na+、K+-ATP酶的活性，而Rbl则抑制Ca2+、Mg2+-ATP酶和钙调蛋白的活性。鉴于[Ca2+]i水平与衰老密切相关，我们的结果表明，Rbl和Rgl诱导的[Ca2+]i变化可能为它们的抗衰老功能机制提供一种解释。
