Wu Y, Qian H
People's Hospital, Beijing Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1995 Jun;30(6):366-8.
Gestational trophoblastic neoplasm treated by large dosage of 5-fluorouracil and actinomycin could cause cardiotoxicity. In 6 cases of gestational trophoblastic neoplasms admitted to our hospital from March to December 1993, cardiotoxicity was found to have occurred after chemotherapies in 10/21 courses. There were 2 cases with heart failures, 4 cases with palpitation and 4 cases with feelings of oppression and (or) chest pains. In 7 cases the electrocardiogram (EKG) findings were abnormal (70.0%) and in 5 cases there were increased sera glutamic oxalacetic transaminase enzyme (AST). 90.0% of these complications were brought under control after decreasing the dosages and changing the methods of administration. If the proper managements were not given on time, patient may even expire. So attention should be paid to this complication. It is suggested that attention should be paid to patients' subjective symptoms, and proper surveillance by EKG and serum AST determinations should be conducted to minimize deaths due to chemotherapeutic complications.
大剂量5-氟尿嘧啶和放线菌素治疗妊娠滋养细胞肿瘤可引起心脏毒性。在1993年3月至12月我院收治的6例妊娠滋养细胞肿瘤患者中，21个疗程化疗后有10个疗程出现心脏毒性。有2例发生心力衰竭，4例有心悸，4例有压迫感和（或）胸痛。7例心电图（EKG）检查结果异常（70.0%），5例血清谷氨酸草酰乙酸转氨酶（AST）升高。降低剂量并改变给药方法后，90.0%的这些并发症得到了控制。若不及时给予恰当处理，患者甚至可能死亡。因此应重视这一并发症。建议关注患者的主观症状，并通过心电图和血清AST测定进行适当监测，以尽量减少化疗并发症导致的死亡。
