Suehiro T, Ohguro T, Sumiyoshi R, Yasuoka N, Nakauchi Y, Kumon Y, Hashimoto K
Second Department of Internal Medicine, Kochi Medical School, Japan.
Diabetes Care. 1995 Mar;18(3):333-8. doi: 10.2337/diacare.18.3.333.
To determine the clinical characteristics of patients with small low-density lipoprotein (LDL) particles among Japanese men with mild glucose intolerance and to investigate the relationship of LDL particle size to the levels of other plasma lipoproteins, obesity, insulin resistance, and blood pressure (BP).
The subjects were 40 men with impaired glucose tolerance or diabetes treated by diet alone, and 40 healthy men matched for age and body mass index (BMI) were used as control subjects. LDL particle size was measured using gradient gel electrophoresis.
Of the 40 patients with glucose intolerance, 19 had small LDL (particle size < 25.5 nm) compared with only 4 of the 40 control subjects. In the patients with small LDL, the plasma levels of cholesterol, triglycerides, and apolipoprotein B, the fasting serum immunoreactive insulin, and the waist-to-hip ratio were all higher than in the patients with normal LDL (particle size > or = 25.5 nm), while the high-density lipoprotein cholesterol level was lower. However, there were no significant differences in BMI, BP, or insulin sensitivity in a euglycemic clamp study between the small-LDL and normal-LDL subgroups.
Japanese men with glucose intolerance frequently have small LDL, and this abnormality is associated with other dyslipoproteinemias and increased waist-to-hip ratio.
确定轻度糖耐量异常的日本男性中低密度脂蛋白（LDL）颗粒较小的患者的临床特征，并研究LDL颗粒大小与其他血浆脂蛋白水平、肥胖、胰岛素抵抗和血压（BP）之间的关系。
研究对象为40例仅通过饮食治疗的糖耐量受损或糖尿病男性患者，40例年龄和体重指数（BMI）匹配的健康男性作为对照。采用梯度凝胶电泳法测量LDL颗粒大小。
40例糖耐量异常患者中，19例LDL颗粒较小（颗粒大小<25.5nm），而40例对照者中只有4例如此。LDL颗粒较小的患者，其血浆胆固醇、甘油三酯和载脂蛋白B水平、空腹血清免疫反应性胰岛素以及腰臀比均高于LDL颗粒正常（颗粒大小≥25.5nm）的患者，而高密度脂蛋白胆固醇水平较低。然而，在正常血糖钳夹研究中，LDL颗粒较小和正常的亚组之间在BMI、BP或胰岛素敏感性方面没有显著差异。
糖耐量异常的日本男性经常存在LDL颗粒较小的情况，这种异常与其他脂蛋白异常血症和腰臀比增加有关。
