Vervoort M, Zink D, Pujol N, Victoir K, Dumont N, Ghysen A, Dambly-Chaudière C
Laboratoire de Génétique du Développement, Université Libre de Bruxelles, Belgium.
Development. 1995 Sep;121(9):3111-20. doi: 10.1242/dev.121.9.3111.
Two genes involved in defining the type of sense organ have been identified in Drosophila. The gene cut differentiates the external sense organs (where it is expressed) from the chordotonal organs (where it is not); among the external sense organs poxn differentiates the poly-innervated organs (where it is expressed) from the mono-innervated organs (where it is not). Here we show that the expression of poxn in normal embryos does not depend on cut, and that poxn is capable of inducing the expression of cut. We have identified a small domain of the very large cut regulatory region as a likely target for activation by poxn.
在果蝇中已鉴定出两个参与定义感觉器官类型的基因。cut基因将外部感觉器官（其在此处表达）与弦音器官（其不在此处表达）区分开来；在外部感觉器官中，poxn基因将多神经支配的器官（其在此处表达）与单神经支配的器官（其不在此处表达）区分开来。在此我们表明，正常胚胎中poxn的表达不依赖于cut，并且poxn能够诱导cut的表达。我们已确定非常大的cut调控区域中的一个小区域可能是poxn激活的靶点。
