Brewster R, Bodmer R
Department of Biology, University of Michigan, Ann Arbor 48109-1048, USA.
Development. 1995 Sep;121(9):2923-36. doi: 10.1242/dev.121.9.2923.
The peripheral nervous system (PNS) of Drosophila is a preferred model for studying the genetic basis of neurogenesis because its simple and stereotyped pattern makes it ideal for mutant analysis. Type I sensory organs, the external (bristle-type) sensory organs (es) and the internal (stretch-receptive) chordotonal organs (ch), have been postulated to derive from individual ectodermal precursor cells that undergo a stereotyped pattern of cell division. Little is known about the origin and specification of type II sensory neurons, the multiple dendritic (md) neurons. Using the flp/FRT recombinase system from yeast, we have determined that a subset of md neurons derives from es organ lineages, another subset derives from ch organ lineages and a third subset is unrelated to sensory organs. We also provide evidence that the genes, numb and cut, are both required for the proper differentiation of md neurons.
果蝇的外周神经系统（PNS）是研究神经发生遗传基础的理想模型，因为其简单且模式化的结构使其成为突变分析的理想对象。I型感觉器官，即外部（刚毛型）感觉器官（es）和内部（拉伸感受型）弦音器官（ch），被认为源自经历定型细胞分裂模式的单个外胚层前体细胞。关于II型感觉神经元，即多树突（md）神经元的起源和特化知之甚少。利用来自酵母的flp/FRT重组酶系统，我们确定了md神经元的一个子集源自es器官谱系，另一个子集源自ch器官谱系，第三个子集与感觉器官无关。我们还提供证据表明，基因numb和cut是md神经元正常分化所必需的。
