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ErbB3 and ErbB2/neu mediate the effect of heregulin on acetylcholine receptor gene expression in muscle: differential expression at the endplate.

作者信息

Altiok N, Bessereau J L, Changeux J P

机构信息

CNRS UA D1284 Neurobiologie Moléculaire, Institut Pasteur, Paris, France.

出版信息

EMBO J. 1995 Sep 1;14(17):4258-66. doi: 10.1002/j.1460-2075.1995.tb00100.x.

DOI:10.1002/j.1460-2075.1995.tb00100.x
PMID:7556067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC394509/
Abstract

Motor neurons modulate acetylcholine receptor (AChR) gene expression in skeletal muscle by two signalling pathways: the transmitter-evoked depolarization of muscle membrane inhibits AChR gene transcription throughout the myofibre presumably via activation of a serine/threonine kinase, while the transcription rates of AChR genes in the synaptic region are increased by nerve-derived trophic factors including AChR-inducing activity (ARIA). To gain further insight into these interactions we characterized the receptor for heregulin (HRG)/ARIA in muscle. We showed that HRG increases AChR alpha-subunit mRNA levels via tyrosine phosphorylation of ErbB3 and ErbB2/neu in myotubes. The protein tyrosine phosphatase inhibitor, pervanadate, potentiated the responses to HRG that were in turn blocked by the tyrosine kinase inhibitor erstatin, indicating the relevance of tyrosine phosphorylation to these events. The effects of HRG were inhibited by enhanced cellular serine/threonine phosphorylation which has been implicated in the repression of AChR genes by electrical activity. Immunocytochemical analysis of adult rat muscle revealed that while ErbB2/neu is present throughout the entire surface of the myofibre membrane, ErbB3 expression is exclusively restricted to the endplate suggesting its involvement in synapse-specific transcription of AChR genes by HRG/ARIA.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/eb4503a83d8a/emboj00041-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/90203e4b267d/emboj00041-0147-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/afe4fa9f1f33/emboj00041-0148-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/169bc6d5db1a/emboj00041-0148-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/50a6f3fd0035/emboj00041-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/76c3e52eb90b/emboj00041-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/eb4503a83d8a/emboj00041-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/90203e4b267d/emboj00041-0147-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/afe4fa9f1f33/emboj00041-0148-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/169bc6d5db1a/emboj00041-0148-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/50a6f3fd0035/emboj00041-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/76c3e52eb90b/emboj00041-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d4/394509/eb4503a83d8a/emboj00041-0151-a.jpg

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本文引用的文献

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Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells.erbB - 3酪氨酸激酶的配体依赖性信号传导及其在人乳腺肿瘤细胞中的组成性激活的证明。
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2900-4. doi: 10.1073/pnas.90.7.2900.
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ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family.ARIA是一种刺激乙酰胆碱受体合成的蛋白质，是神经配体家族的成员。
Cell. 1993 Mar 12;72(5):801-15. doi: 10.1016/0092-8674(93)90407-h.
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Synapse-specific gene expression.
重症肌无力的遗传风险基因座鉴定和基因及通路的优先级排序：全基因组关联研究。
Proc Natl Acad Sci U S A. 2022 Feb 1;119(5). doi: 10.1073/pnas.2108672119.
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Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity.神经调节蛋白，一种作用于线粒体代谢以维持胰岛素敏感性的效应因子。
Front Physiol. 2020 Jun 23;11:696. doi: 10.3389/fphys.2020.00696. eCollection 2020.
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Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction.细胞外基质蛋白及其受体在脊椎动物神经肌肉接头发育中的作用。
Dev Neurobiol. 2011 Nov;71(11):982-1005. doi: 10.1002/dneu.20953.
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