Shehabi A A
Department of Pathology-Microbiology, Faculty of Medicine, Jordan University, Amman.
Eur J Clin Microbiol Infect Dis. 1995 May;14(5):448-51. doi: 10.1007/BF02114903.
During the 12-year period from 1978 to 1989, Salmonella typhimurium was the most frequently isolated serotype (592/1,500; 39.5%) among all clinical Salmonella isolates at Jordan University Hospital. Extra-intestinal infections due to Salmonella typhimurium accounted for 68 (11.5%) isolates. A high percentage of Salmonella typhimurium strains (52-90%) were resistant to commonly used drugs in Jordan. Most of the antibiotic-resistant strains of Salmonella typhimurium (10/12) examined which were from extra-intestinal sources contained a large plasmid (55 MDa) in addition to two to four small plasmids. These strains were also able to transfer most or part of their drug resistance in vitro. It is concluded that the invasive potential of Salmonella typhimurium isolates is probably associated with the presence of a large virulence plasmid and multiple antibiotic resistance.
在1978年至1989年的12年期间，鼠伤寒沙门氏菌是约旦大学医院所有临床沙门氏菌分离株中最常分离出的血清型（592/1500；39.5%）。鼠伤寒沙门氏菌引起的肠外感染占68株（11.5%）。约旦的鼠伤寒沙门氏菌菌株对常用药物有很高比例（52 - 90%）的耐药性。所检测的大多数来自肠外来源的鼠伤寒沙门氏菌耐药菌株（10/12）除了含有两到四个小质粒外，还含有一个大质粒（55 MDa）。这些菌株在体外也能够转移其大部分或部分耐药性。结论是，鼠伤寒沙门氏菌分离株的侵袭潜力可能与一个大的毒力质粒的存在和多重抗生素耐药性有关。
