Koguchi A, Nomura K, Fujiwara T, Kawai Y, Okaniwa A
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Exp Anim. 1995 Jul;44(3):251-3. doi: 10.1538/expanim.44.251.
Three thumb-sized segmental swellings were found in both uterine horns of a 15 month-old, non-pregnant and non-pseudopregnant female beagle dog. Histopathological examination of the uterus revealed a marked proliferation of the endometrium that was characterized by two distinct parts, an inner tightly-folded banded layer and an outer dilated spongy layer, quite similar to the maternal placenta except for the fetus and chorion in the lumen. Because the plasma level of progesterone was unusually high at autopsy, this hormonal disorder might be related to the pathogenesis of the endometrial hyperplasia in the present case.
在一只15个月大、未怀孕且未假孕的雌性比格犬的双侧子宫角中发现了三个拇指大小的节段性肿胀。子宫的组织病理学检查显示子宫内膜明显增生，其特征为两个不同的部分，一个内部紧密折叠的带状层和一个外部扩张的海绵层，除管腔内的胎儿和绒毛膜外，与母体胎盘非常相似。由于尸检时孕酮的血浆水平异常高，这种激素紊乱可能与本病例中子宫内膜增生的发病机制有关。
