Quirion R, Rioux F, Regoli D
Clin Exp Hypertens (1978). 1978;1(2):267-77. doi: 10.3109/10641967809068608.
The intravenous infusion of indomethacin (5 mg/kg/min) for 10 min did not modify the systolic blood pressure of conscious, unrestrained doca/salt hypertensive, spontaneously hypertensive (SH) and normotensive Wistar (NW) rats. However, this dose of indomethacin was sufficient to prevent completely the hypotensive action of arachidonic acid in these animals. The chronic administration of indomethacin to doca/salt treated- and young SH rats was without any effect on the development of hypertension in these animals. These results suggest a limited role for endogenous PGs during the development of these two types of hypertension.
静脉输注吲哚美辛（5毫克/千克/分钟）10分钟，对清醒、未受限制的去氧皮质酮/盐性高血压大鼠、自发性高血压（SH）大鼠和正常血压的Wistar（NW）大鼠的收缩压没有影响。然而，该剂量的吲哚美辛足以完全防止花生四烯酸对这些动物的降压作用。对接受去氧皮质酮/盐治疗的大鼠和年轻SH大鼠长期给予吲哚美辛，对这些动物高血压的发展没有任何影响。这些结果表明内源性前列腺素在这两种类型高血压的发展过程中作用有限。
