Rioux F, Quirion R, Regoli D
Can J Physiol Pharmacol. 1977 Dec;55(6):1330-8. doi: 10.1139/y77-178.
The release of prostaglandin-like (PG-like) material by aorta strips of normotensive and hypertensive rats has been studied in vitro. When incubated in an oxygenated Krebs solution kept at 37 degrees C, aorta strips removed from 8- and 12-week-old spontaneously hypertensive (SH) rats generate 1.2-2.5 times more PG-like material than aorta strips from age-matched normotensive Wistar (NW) rats. The overproduction of PG-like material by aorta strips of SH rats did not precede the development of hypertension in SH rats. Aorta strips derived from renal and DOCA-salt hypertensive rats produced 1.5-3 times more PG-like material than aorta strips from NW rats. The production of PG-like material by aorta strips of renal and DOCA-salt hypertensive rats was largely reduced when hypertension was interrupted in these animals, thus suggesting that the alteration taking place in the arteries of hypertensive rats (namely increased production of PGs) during the development of hypertension was reversible. The production of PG-like material by aorta strips of hypertensive rats was inhibited by indomethacin. Analysis of the PG-like material by bioassays and thin-layer chromatography suggests the presence of PGE2 and PGE1. The possible involvement of these PGs in the pathogenesis of hypertension in rats is discussed.
已在体外研究了正常血压和高血压大鼠主动脉条释放类前列腺素（PG样）物质的情况。将取自8周龄和12周龄自发性高血压（SH）大鼠的主动脉条在37℃的含氧Krebs溶液中孵育时，其产生的PG样物质比年龄匹配的正常血压Wistar（NW）大鼠的主动脉条多1.2至2.5倍。SH大鼠主动脉条PG样物质的过度产生在SH大鼠高血压发展之前并未出现。源自肾性高血压和去氧皮质酮盐性高血压大鼠的主动脉条产生的PG样物质比NW大鼠的主动脉条多1.5至3倍。当这些动物的高血压被阻断时，肾性高血压和去氧皮质酮盐性高血压大鼠主动脉条PG样物质的产生大幅减少，这表明高血压发展过程中高血压大鼠动脉中发生的改变（即PGs产生增加）是可逆的。消炎痛抑制高血压大鼠主动脉条PG样物质的产生。通过生物测定和薄层色谱法对PG样物质的分析表明存在PGE2和PGE1。讨论了这些PGs可能参与大鼠高血压发病机制的情况。
