The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart.

作者信息

Pavlović M, Petković D, Cvetković M, Macut D J, Zdjelar K, Nesić M, Bosnić O, Radulović R, Mihajlović M

机构信息

Institute of Physiology, Faculty of Medicine, University of Belgrade, Yugoslavia.

出版信息

Experientia. 1995 Sep 29;51(9-10):941-4. doi: 10.1007/BF01921744.

The mechanism of the positive inotropic effect of prostacyclin (PGI2) (2.6 x 10(-6) mol/l) on the isolated right ventricle of rat heart was studied. Our results show that the positive inotropic effect of prostacyclin is produced indirectly through beta adrenoceptors and slow Ca2+ channels, because blockade of slow Ca2+ channels with verapamil (10(-6) mol/l) and beta adrenoceptors with propranolol (10(-6) mol/l) abolishes this effect. Alpha adrenoceptors do not mediate the action of PGI2.