Vareli K, Frangou-Lazaridis M, Tsolas O
Laboratory of Biological Chemistry, University of Ioannina Medical School, Greece.
FEBS Lett. 1995 Sep 11;371(3):337-40. doi: 10.1016/0014-5793(95)00938-6.
Expression of prothymosin alpha, an acidic nuclear protein implicated in cellular proliferation, has been reported to be regulated by c-myc in vitro. We have studied the correlation of expression levels between prothymosin alpha and c-myc, using three different in vivo systems, viz. normal ontogenic process of placental development, lytic viral infection and heat shock treatment. The two genes have been found to share a similar expression pattern, although prothymosin alpha mRNA remains always detectable, indicating the existence of yet another mechanism, in addition to c-myc, which regulates its expression in vivo.
胸腺素α原是一种与细胞增殖有关的酸性核蛋白，据报道其表达在体外受c-myc调控。我们利用三种不同的体内系统，即胎盘发育的正常个体发育过程、溶细胞病毒感染和热休克处理，研究了胸腺素α原与c-myc表达水平之间的相关性。尽管胸腺素α原mRNA始终可检测到，但已发现这两个基因具有相似的表达模式，这表明除了c-myc之外，还存在另一种在体内调节其表达的机制。
