异氟烷的生殖及致畸学研究。

Reproductive and teratologic studies with isoflurane.

作者信息

Kennedy G L, Smith S H, Keplinger M L, Calandra J C

出版信息

Drug Chem Toxicol. 1977;1(1):75-88. doi: 10.3109/01480547709034428.

Abstract

The volatile anesthetic, Isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether), was investigated at anesthetic concentrations to determine its effects on reproduction in rats treated prior to mating, on fetal development in rats and rabbits when administered during various stages of gestation, and on fetal survival in rats treated during late pregnancy. No adverse reproductive effects were observed, and no evidence of teratogenic activity was obtained. Fetal survival was low in rats exposed during late pregnancy but whether or not this finding is related to Isoflurane exposure requires confirmation.

摘要

对挥发性麻醉剂异氟烷（1-氯-2,2,2-三氟乙基二氟甲基醚）在麻醉浓度下进行了研究，以确定其对交配前处理的大鼠繁殖的影响、在妊娠各阶段给药时对大鼠和家兔胎儿发育的影响，以及对妊娠后期处理的大鼠胎儿存活的影响。未观察到不良生殖影响，也未获得致畸活性的证据。妊娠后期暴露的大鼠胎儿存活率较低，但这一发现是否与异氟烷暴露有关尚需证实。