Lynch D W, Perone V B, Schuler R L, Ushry W B, Lewis T R
Drug Chem Toxicol. 1978;1(3):219-30. doi: 10.3109/01480547809105016.
Oral LD50 (rat), primary skin irritation (rabbit), cutaneous sensitization (guinea pig) and eye irritation (rabbit) studies were conducted on the three tetramethylbenzene isomers: durene , isodurene and prehnitene. The order of oral toxicity was isodurene greater than prehnitene greater durene. Durene was not a skin irritant, while isodurene and prehnitene each produced a mild positive skin response (erythema). None of the tetramethylbenzenes were skin sensitizers or eye irritants. Durene, isodurene and prehnitene are only slightly toxic on an acute toxicologic basis and only pose an acute health hazard when injested in excessive quantities.
对三种四甲基苯异构体均四甲苯、异均四甲苯和连四甲苯进行了口服半数致死剂量（大鼠）、原发性皮肤刺激（家兔）、皮肤致敏（豚鼠）和眼刺激（家兔）研究。口服毒性顺序为异均四甲苯＞连四甲苯＞均四甲苯。均四甲苯不是皮肤刺激物，而异均四甲苯和连四甲苯各自产生轻度阳性皮肤反应（红斑）。这些四甲基苯均不是皮肤致敏剂或眼刺激物。均四甲苯、异均四甲苯和连四甲苯在急性毒理学基础上毒性轻微，仅在过量摄入时才会造成急性健康危害。
