Levy S G, Kirkness C M, Moss J, Ficker L, McCartney A C
Department of Pathology, Institute of Ophthalmology, London, UK.
Eye (Lond). 1995;9 ( Pt 3):318-23. doi: 10.1038/eye.1995.62.
The iridocorneal-endothelial syndrome (ICE syndrome) is characterised by corneal failure, glaucoma and iris destruction. Specular photomicroscopical and histological studies of the corneal endothelium in this disease show a population of abnormal cells named 'ICE-cells'. In many patients some areas of the endothelium are occupied by ICE-cells and others by normal cells, an appearance described as 'subtotal-ICE'. Specular photomicroscopical observations suggest that ICE-cells and normal endothelial cells may actively interact at the boundary zone where they meet. The purpose of this study was to examine the ultrastructural appearances of the boundary zone to gain insight into the cellular pathology of this region. Thirty-five corneas taken from patients with the ICE syndrome were examined by light, transmission and scanning electron microscopy. The subtotal-ICE appearance was demonstrated in four specimens. The morphology of ICE-cells at the boundary zone suggests that they are non-motile but also implies a general state of high metabolic activity. Many of the normal endothelial cells in this region are damaged, an appearance which may result from a toxic effect from the nearby ICE-cells.
虹膜角膜内皮综合征（ICE综合征）的特征是角膜衰竭、青光眼和虹膜破坏。对该疾病角膜内皮的镜面反射显微镜检查和组织学研究显示存在一群名为“ICE细胞”的异常细胞。在许多患者中，内皮的一些区域被ICE细胞占据，而其他区域被正常细胞占据，这种表现被描述为“部分ICE”。镜面反射显微镜观察表明，ICE细胞和正常内皮细胞可能在它们相遇的边界区域积极相互作用。本研究的目的是检查边界区域的超微结构外观，以深入了解该区域的细胞病理学。对35例ICE综合征患者的角膜进行了光镜、透射电镜和扫描电镜检查。在4个标本中显示出部分ICE的外观。边界区域ICE细胞的形态表明它们不具有运动性，但也暗示了高代谢活性的一般状态。该区域许多正常内皮细胞受损，这种表现可能是由附近ICE细胞的毒性作用导致的。
