Gilman M R, Evans R A, De Salva S J
Drug Chem Toxicol. 1978;1(4):391-400. doi: 10.3109/01480547809016050.
The Primary Rabbit Dermal Irritation Assay as described in the Federal Hazardous Substances Act (FHSA) is used by the Consumer Products Safety Commission (CPSC) to determine the labeling requirements of household products. One of the more obvious deficiencies of this assay is the descriptive imprecision for preparing the form in which solid materials are applied. Our experimental findings show that form and concentration of test material as well as the length of contact with the skin and the degree of patch occlusivity are prime factors influencing the degree of skin change. Four detergent granular products are evaluated. In the dry powder form with 4 hour exposure all the detergents were non-irritating. The paste at 24 hours under total occlusion was the most irritating.
消费品安全委员会（CPSC）采用《联邦有害物质法》（FHSA）中描述的初级兔皮肤刺激试验来确定家用产品的标签要求。该试验较为明显的缺陷之一是在制备用于涂抹固体材料的形式时描述不精确。我们的实验结果表明，测试材料的形式和浓度、与皮肤接触的时间以及贴片封闭程度是影响皮肤变化程度的主要因素。对四种洗涤剂颗粒产品进行了评估。在干粉形式下暴露4小时，所有洗涤剂均无刺激性。在完全封闭条件下放置24小时的糊剂刺激性最强。
