雄激素诱导的小鼠肾脏中鸟氨酸脱羧酶的神经元调节

Neuronal regulation of ornithine decarboxylase induced by androgens in the mouse kidney.

Tovar A, Peñuela A, Sánchez-Capelo A, Monserrat F, Cremades A, Peñafiel R

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Murcia, Spain.

Gen Pharmacol. 1995 Sep;26(5):997-1001. doi: 10.1016/0306-3623(94)00287-w.

Abstract

Neuronal, but not circulating catecholamines, regulate the induction of ornithine decarboxylase (ODC) by testosterone in the mouse kidney. 2. Central and peripheral catecholamine-depleting agents, such as reserpine or alpha-methyl-p-tyrosine, exerted a more pronounced effect on renal ODC than the selective agents tetrabenazine or guanethidine. 3. Benserazide and haloperidol decreased the induction of renal ODC produced by testosterone in female mice. 4. Renal denervation produced a partial inhibition of renal ODC in male mice and decreased the induction of ODC elicited by testosterone in female mice. 5. These results suggest that both peripheral sympathetic neurons as well as central related factors can modulate the effect of androgens on renal ODC activity.

摘要

神经元而非循环中的儿茶酚胺调节睾酮对小鼠肾脏中鸟氨酸脱羧酶（ODC）的诱导作用。2. 中枢和外周儿茶酚胺耗竭剂，如利血平或α-甲基对酪氨酸，对肾脏ODC的作用比选择性药物丁苯那嗪或胍乙啶更为显著。3. 苄丝肼和氟哌啶醇降低了睾酮对雌性小鼠肾脏ODC的诱导作用。4. 肾脏去神经支配对雄性小鼠的肾脏ODC产生部分抑制作用，并降低了睾酮对雌性小鼠ODC的诱导作用。5. 这些结果表明，外周交感神经元以及中枢相关因素均可调节雄激素对肾脏ODC活性的影响。