布氏锥虫磷酸甘油酸激酶编码基因的3'非翻译区介导发育调控。
The 3'-untranslated regions from the Trypanosoma brucei phosphoglycerate kinase-encoding genes mediate developmental regulation.
作者信息
Blattner J, Clayton C E
机构信息
Zentrum für Molekulare Biologie, Universität Heidelberg, Germany.
出版信息
Gene. 1995 Aug 30;162(1):153-6. doi: 10.1016/0378-1119(95)00366-e.
PMID:7557405
Abstract
The phosphoglycerate kinase (PGK)-encoding genes of Trypanosoma brucei are transcribed in a polycistronic fashion, but the mRNAs encoding the three PGK isozymes show differing developmental regulation. We demonstrate here that the 3'-untranslated regions of the major cytoplasmic and glycosomal PGK isozymes are capable of conferring the anticipated types of regulation on a transfected reporter gene.
摘要
布氏锥虫的磷酸甘油酸激酶（PGK）编码基因以多顺反子的方式转录，但编码三种PGK同工酶的mRNA表现出不同的发育调控。我们在此证明，主要细胞质和糖体PGK同工酶的3'非翻译区能够对转染的报告基因赋予预期的调控类型。
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