Zhao Mirabella, Liao Donghua, Zhao Jingbo
Mirabella Zhao, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
World J Diabetes. 2017 Jun 15;8(6):249-269. doi: 10.4239/wjd.v8.i6.249.
The disorders of gastrointestinal (GI) tract including intestine and colon are common in the patients with diabetes mellitus (DM). DM induced intestinal and colonic structural and biomechanical remodeling in animals and humans. The remodeling is closely related to motor-sensory abnormalities of the intestine and colon which are associated with the symptoms frequently encountered in patients with DM such as diarrhea and constipation. In this review, firstly we review DM-induced histomorphological and biomechanical remodeling of intestine and colon. Secondly we review motor-sensory dysfunction and how they relate to intestinal and colonic abnormalities. Finally the clinical consequences of DM-induced changes in the intestine and colon including diarrhea, constipation, gut microbiota change and colon cancer are discussed. The final goal is to increase the understanding of DM-induced changes in the gut and the subsequent clinical consequences in order to provide the clinicians with a better understanding of the GI disorders in diabetic patients and facilitates treatments tailored to these patients.
胃肠道（GI）疾病，包括小肠和结肠疾病，在糖尿病（DM）患者中很常见。糖尿病会在动物和人类中引发小肠和结肠的结构及生物力学重塑。这种重塑与小肠和结肠的运动感觉异常密切相关，而这些异常又与糖尿病患者经常出现的腹泻和便秘等症状有关。在这篇综述中，首先我们回顾糖尿病引发的小肠和结肠组织形态学及生物力学重塑。其次我们回顾运动感觉功能障碍以及它们与小肠和结肠异常的关系。最后讨论糖尿病引发的小肠和结肠变化的临床后果，包括腹泻、便秘、肠道微生物群改变和结肠癌。最终目标是增进对糖尿病引发的肠道变化及其后续临床后果的理解，以便为临床医生提供对糖尿病患者胃肠道疾病更好的理解，并促进针对这些患者的个性化治疗。
