源自人脑cDNA文库的三核苷酸重复序列中的多态性（α1-抗胰蛋白酶）

Polymorphic (AAT) in trinucleotide repeats derived from a human brain cDNA library.

作者信息

Margolis R L, Breschel T S, Li S H, Kidwai A S, McInnis M G, Ross C A

机构信息

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.

出版信息

Hum Genet. 1995 Oct;96(4):495-6. doi: 10.1007/BF00191817.

DOI:10.1007/BF00191817

PMID:7557981

Abstract

Seven cDNA fragments containing polymorphic (AAT)n trinucleotide repeats were isolated from a human brain cDNA library and mapped by linkage to specific loci. These repeats may serve as gene markers or as candidates for diseases caused by expansion mutation.

摘要

从人脑cDNA文库中分离出7个含有多态性(AAT)n三核苷酸重复序列的cDNA片段，并通过与特定基因座的连锁进行定位。这些重复序列可作为基因标记或由扩增突变引起的疾病的候选基因。