人类基因组的第二代连锁图谱。

A second-generation linkage map of the human genome.

作者信息

Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P, Vaysseix G, Lathrop M

机构信息

Genethon, Evry, France.

出版信息

Nature. 1992 Oct 29;359(6398):794-801. doi: 10.1038/359794a0.

DOI:10.1038/359794a0

PMID:1436057

Abstract

A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome.

摘要

基于对来自八个大家族的一组DNA中814个新鉴定的包含短串联（C-A）n重复序列的多态性位点的分离分析，构建了人类基因组的连锁图谱。统计连锁分析将813个标记定位到23个连锁群中，分别对应22条常染色体和X染色体；605个标记的杂合度高于0.7，553个标记的排序优势比高于1000:1。所覆盖的距离约占人类基因组估计长度的90%。