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CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19.

作者信息

Mock B A, Connelly M A, McBride O W, Kozak C A, Marcu K B

机构信息

Laboratory of Genetics and Biochemistry, NCI, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Genomics. 1995 May 20;27(2):348-51. doi: 10.1006/geno.1995.1054.

DOI:10.1006/geno.1995.1054
PMID:7558004
Abstract

Helix-loop-helix proteins contain stretches of DNA that encode two amphipathic alpha-helices joined by a loop structure and are involved in protein dimerization and transcriptional regulation essential to a variety of cellular processes. CHUK, a newly described conserved helix-loop-helix ubiquitous kinase, was mapped by somatic cell hybrid analyses to human Chr 10q24-q25. Chuk and a related sequence, Chuk-rs1, were mapped to mouse chromosomes 19 and 16, respectively, by a combination of somatic cell hybrid, recombinant inbred, and backcross analyses.

摘要

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