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A high-resolution interval map of the q21 region of the human X chromosome.

作者信息

Philippe C, Arnould C, Sloan F, van Bokhoven H, van der Velde-Visser S D, Chery M, Ropers H H, Gilgenkrantz S, Monaco A P, Cremers F P

机构信息

ICRF Laboratories, Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom.

出版信息

Genomics. 1995 Jun 10;27(3):539-43. doi: 10.1006/geno.1995.1089.

Abstract

In a previous study, we have developed a panel of chromosomal rearrangements for the physical mapping of the q13-q21 region of the human X chromosome (Philippe et al., Genomics 17: 147-152, 1993). Here, we report the physical localization of 36 additional polymorphic markers by polymerase chain reaction analysis. The high density of chromosomal breakpoints in Xq21 allows us to map 58 DNA loci in 22 intervals. As a result, this segment of the X chromosome is saturated with approximately three sequence tagged sites per megabase of DNA, which will facilitate the construction of a YAC contig of this region.

摘要

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