脑膜炎奈瑟菌70千道尔顿铁调节外膜蛋白FrpB的分子特征
Molecular characterization of FrpB, the 70-kilodalton iron-regulated outer membrane protein of Neisseria meningitidis.
作者信息
Pettersson A, Maas A, van Wassenaar D, van der Ley P, Tommassen J
机构信息
Department of Molecular Cell Biology, Utrecht University, The Netherlands.
出版信息
Infect Immun. 1995 Oct;63(10):4181-4. doi: 10.1128/iai.63.10.4181-4184.1995.
Abstract
The structural gene encoding the 70-kDa outer membrane protein FrpB of Neisseria meningitidis was cloned and sequenced. A mutant lacking FrpB was constructed. No difference in iron utilization between the mutant and the parental strain was observed. A minor effect of the mutation on serum resistance was observed. A topology model for FrpB in the outer membrane is proposed.
摘要
对脑膜炎奈瑟菌70 kDa外膜蛋白FrpB的编码结构基因进行了克隆和测序。构建了一个缺失FrpB的突变体。未观察到该突变体与亲本菌株在铁利用方面的差异。观察到该突变对血清抗性有轻微影响。提出了外膜中FrpB的拓扑模型。
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