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本文引用的文献

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NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
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Phase variation of H. influenzae fimbriae: transcriptional control of two divergent genes through a variable combined promoter region.流感嗜血杆菌菌毛的相变：通过可变组合启动子区域对两个反向基因进行转录调控。
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Neisseria meningitidis produces iron-regulated proteins related to the RTX family of exoproteins.脑膜炎奈瑟菌产生与外毒素RTX家族相关的铁调节蛋白。
J Bacteriol. 1993 Feb;175(3):811-8. doi: 10.1128/jb.175.3.811-818.1993.
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Molecular characterization of the 98-kilodalton iron-regulated outer membrane protein of Neisseria meningitidis.脑膜炎奈瑟菌98千道尔顿铁调节外膜蛋白的分子特征
Infect Immun. 1993 Nov;61(11):4724-33. doi: 10.1128/iai.61.11.4724-4733.1993.
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Identification and cloning of a fur homolog from Neisseria gonorrhoeae.淋病奈瑟菌中一个铁摄取调节蛋白同源物的鉴定与克隆。
Infect Immun. 1993 Nov;61(11):4599-606. doi: 10.1128/iai.61.11.4599-4606.1993.
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Cloning and characterization of the Vibrio cholerae genes encoding the utilization of iron from haemin and haemoglobin.霍乱弧菌编码利用血红素和血红蛋白中铁元素的基因的克隆与特性分析。
Mol Microbiol. 1993 Feb;7(3):461-9. doi: 10.1111/j.1365-2958.1993.tb01137.x.
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A mutation affecting expression of a major outer membrane protein of Moraxella catarrhalis alters serum resistance and survival in vivo.一种影响卡他莫拉菌主要外膜蛋白表达的突变会改变血清抗性及体内存活率。
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Identification and cloning of a fur homologue from Neisseria meningitidis.从脑膜炎奈瑟菌中鉴定并克隆铁摄取调节蛋白（Fur）同源物
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9
Gonococcal transferrin-binding protein 2 facilitates but is not essential for transferrin utilization.淋球菌转铁蛋白结合蛋白2有助于转铁蛋白的利用，但并非必不可少。
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10
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淋病奈瑟菌主要铁调节外膜蛋白FrpB编码基因的克隆、测序及特性分析

Cloning, sequencing, and characterization of the gene encoding FrpB, a major iron-regulated, outer membrane protein of Neisseria gonorrhoeae.

作者信息

Beucher M, Sparling P F

机构信息

Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill 27599, USA.

出版信息

J Bacteriol. 1995 Apr;177(8):2041-9. doi: 10.1128/jb.177.8.2041-2049.1995.

DOI:10.1128/jb.177.8.2041-2049.1995
PMID:7721696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176847/
Abstract

FrpB (for Fe-regulated protein B) is a 76-kDa outer membrane protein that is part of the iron regulon of Neisseria gonorrhoeae and Neisseria meningitidis. The frpB gene from gonococcal strain FA19 was cloned and sequenced. FrpB was homologous to several TonB-dependent outer membrane receptors of Escherichia coli as well as HemR of Yersinia enterocolitica and CopB of Moraxella catarrhalis. An omga insertion into the frpB coding sequence caused a 60% reduction in 55Fe uptake from heme, but careful analysis suggested that this effect was nonspecific. While FrpB was related to the family of TonB-dependent proteins, a function in iron uptake could not be documented.

摘要

FrpB（铁调节蛋白B）是一种76千道尔顿的外膜蛋白，是淋病奈瑟菌和脑膜炎奈瑟菌铁调节子的一部分。对淋病奈瑟菌菌株FA19的frpB基因进行了克隆和测序。FrpB与大肠杆菌的几种TonB依赖性外膜受体、小肠结肠炎耶尔森菌的HemR以及卡他莫拉菌的CopB具有同源性。在frpB编码序列中插入一个ω元件导致从血红素摄取55Fe的量减少了60%，但仔细分析表明这种效应是非特异性的。虽然FrpB与TonB依赖性蛋白家族有关，但在铁摄取中的功能尚无记录。