Fidel P L, Cutright J L, Sobel J D
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Infect Immun. 1995 Oct;63(10):4191-4. doi: 10.1128/iai.63.10.4191-4194.1995.
Studies to date with CBA/J mice suggest a limited role for systemic cell-mediated immunity (CMI) against vaginal Candida albicans infections. The results of the present study show that preinduced Candida-specific systemic CMI was equally nonprotective against C. albicans vaginal infections in mice with high (BALB/cJ), low (DBA/2), or intermediate (CBA/J) resistance to C. albicans infections. Similarly, the locally acquired partial protection against a second C. albicans vaginal infection was equally observed with BALB/cJ, DBA/2, and CBA/J mice. These results indicate that observations made previously with CBA/J mice were not murine strain specific and provide additional support for the hypothesis that systemic CMI does not represent a dominant host defense mechanism at the vaginal mucosa.
迄今为止，对CBA/J小鼠的研究表明，全身性细胞介导免疫（CMI）在抵抗阴道白色念珠菌感染方面作用有限。本研究结果显示，预先诱导的念珠菌特异性全身性CMI对白色念珠菌感染具有高抵抗力（BALB/cJ）、低抵抗力（DBA/2）或中等抵抗力（CBA/J）的小鼠的白色念珠菌阴道感染同样没有保护作用。同样，BALB/cJ、DBA/2和CBA/J小鼠对第二次白色念珠菌阴道感染均出现了局部获得的部分保护作用。这些结果表明，先前对CBA/J小鼠的观察并非小鼠品系特异性的，并为全身性CMI不是阴道黏膜主要宿主防御机制这一假说提供了额外支持。
