Fidel P L, Lynch M E, Redondo-Lopez V, Sobel J D, Robinson R
Division of Infectious Diseases, Wayne State University, School of Medicine, Detroit, Michigan.
J Infect Dis. 1993 Dec;168(6):1458-65. doi: 10.1093/infdis/168.6.1458.
It has been suggested that impaired cell-mediated immunity (CMI) against Candida antigens is responsible for susceptibility to recurrent vulvovaginal candidiasis (RVVC) in adult women. To address this, we conducted a comprehensive longitudinal study examining in vivo and in vitro systemic CMI reactivity in RVVC patients. Results showed that RVVC patients frequently demonstrated a transient loss of Candida-specific delayed cutaneous skin test reactivity during episodes of symptomatic vaginitis. In contrast, in vitro peripheral blood lymphoproliferation and Th1-type lymphokine production by RVVC patients in response to a T cell mitogen and multiple Candida and bacterial antigens were similar to controls both during acute episodes of vaginitis and during periods of infection-free remission. These results suggest that women with RVVC have no detectable impairment of systemic CMI in peripheral blood and that transient reductions in skin test reactivity appear to be a result of vaginal Candida infection and not a predisposing factor to RVVC.
有观点认为，成年女性复发性外阴阴道念珠菌病（RVVC）易感性与针对念珠菌抗原的细胞介导免疫（CMI）受损有关。为了对此进行研究，我们开展了一项全面的纵向研究，检测RVVC患者体内和体外的全身CMI反应性。结果显示，RVVC患者在症状性阴道炎发作期间，常出现念珠菌特异性迟发性皮肤试验反应性的短暂丧失。相比之下，RVVC患者在阴道炎急性发作期间以及无感染缓解期，其体外外周血淋巴细胞增殖以及对T细胞有丝分裂原、多种念珠菌和细菌抗原产生的Th1型淋巴因子与对照组相似。这些结果表明，RVVC女性外周血中未检测到全身CMI受损，皮肤试验反应性的短暂降低似乎是阴道念珠菌感染的结果，而非RVVC的易感因素。
