Andrews S J, Hole N J, Munn E A, Rolph T P
Mallinckrodt Veterinary Ltd., Harefield, Uxbridge, U.K.
Int J Parasitol. 1995 Jul;25(7):839-46. doi: 10.1016/0020-7519(94)00221-9.
Pregnant ewes were immunised with a fraction highly enriched in the membrane glycoprotein antigen H11, isolated from the intestinal brush border of adult Haemonchus contortus. Immunity induced by immunisation was able to abolish almost completely (98-99%) the worm egg output from pregnant ewes challenged with ca. 10,000 infective larvae of H. contortus during the last trimester. Furthermore, lambs born and reared on vaccinated ewes had substantial antibody levels to H11 derived from maternal transfer. This antibody conferred moderate protection against a bolus challenge of ca. 3000 infective larvae of H. contortus in 5-week-old lambs.
用从成年捻转血矛线虫肠道刷状缘分离出的高度富集膜糖蛋白抗原H11的组分对怀孕母羊进行免疫。免疫诱导的免疫力能够几乎完全消除（98%-99%）在妊娠晚期感染约10,000条捻转血矛线虫感染性幼虫的怀孕母羊的虫卵排出量。此外，在接种疫苗的母羊上出生并饲养的羔羊通过母源传递具有较高水平的针对H11的抗体。这种抗体对5周龄羔羊感染约3000条捻转血矛线虫感染性幼虫的一次大剂量攻击提供了适度的保护。
