Di Francesco P, Gaziano R, Casalinuovo I A, Palamara A T, Favalli C
Department of Experimental Medicine, University of Rome, Tor Vergata, Italy.
Int J Tissue React. 1994;16(5-6):205-10.
The G0/G1 to S-phase transition in quiescent EL2 rat fibroblast cells stimulated by mitogen (such as the epidermal growth factor) can be blocked by the addition of morphine to the system. The drug must be actively present when quiescent EL2 cells are induced to enter the proliferative state. Even when morphine is added after mitogenic stimulus, an exposure only within 6 hours is required to inhibit DNA synthesis. These results suggest that morphine can directly influence the proliferation of the nonlymphoid cell system, particularly during the establishment of a competence state (i.e. G0/S phase transition).
有丝分裂原（如表皮生长因子）刺激静止的EL2大鼠成纤维细胞时，从G0/G1期到S期的转变可因向系统中添加吗啡而受阻。当静止的EL2细胞被诱导进入增殖状态时，药物必须处于活性状态。即使在有丝分裂原刺激后添加吗啡，仅需6小时内的暴露时间就能抑制DNA合成。这些结果表明，吗啡可直接影响非淋巴细胞系统的增殖，尤其是在能力状态建立期间（即G0/S期转变）。
