Selivanova G V, Shemarova I V, Vlasova T D
Institute of Cytology, Russian Academy of Sciences, Tikhoretskii pr. 4, St. Petersburg, 194064 Russia.
Ontogenez. 2002 Nov-Dec;33(6):457-60.
We studied the effect of murine epidermal growth factor on cell proliferation and DNA synthesis in macronuclei of ciliate Tetrahymena pyriformis G1. Mitogenic effect of epidermal growth factor on proliferation-induced tetrahymena cells has been revealed. This effect is due to the induced progression of cells at G1 and, consequently, their earlier entering DNA synthesis phase of the first cell cycle. Epidermal growth factor had no mitogenic effect on the resting cells from stationary culture (G0 phase) whose development is independent of the growth factors in the medium.
我们研究了小鼠表皮生长因子对梨形四膜虫G1大核细胞增殖和DNA合成的影响。已揭示表皮生长因子对增殖诱导的四膜虫细胞具有促有丝分裂作用。这种作用归因于细胞在G1期的诱导进展，从而使其更早进入第一个细胞周期的DNA合成阶段。表皮生长因子对来自静止培养物（G0期）的静止细胞没有促有丝分裂作用，其生长不依赖于培养基中的生长因子。
