Hauschildt S, Kleine B
Institut für Immunobiologie, Universität, Freiburg, Germany.
Int Rev Cytol. 1995;161:263-331. doi: 10.1016/s0074-7696(08)62499-7.
Our current understanding of the interaction between bacteria and macrophages, cells of the immune system that play a major role in the defense against infection, is summarized. Cell-surface structures of Gram-negative and Gram-positive bacteria that account for these interactions are described in detail. Besides surface structures, soluble bacterial molecules, toxins that are derived from pathogenic bacteria, are also shown to modulate macrophage functions. In order to affect macrophage functions, bacterial surface structures have to be recognized by the macrophage and toxins have to be taken up. Subsequently, signal transduction mechanisms are initiated that enable the macrophage to respond to the invading bacteria. To destroy bacteria, macrophages employ many strategies, among which antigen processing and presentation to T cells, phagocytosis, chemotaxis, and different bactericidal mechanisms are considered to be the main weapons.
本文总结了我们目前对细菌与巨噬细胞相互作用的理解，巨噬细胞是免疫系统中的细胞，在抵御感染中发挥着主要作用。详细描述了革兰氏阴性菌和革兰氏阳性菌中导致这些相互作用的细胞表面结构。除了表面结构外，可溶性细菌分子，即源自病原菌的毒素，也被证明可调节巨噬细胞功能。为了影响巨噬细胞功能，细菌表面结构必须被巨噬细胞识别，毒素必须被摄取。随后，启动信号转导机制，使巨噬细胞能够对入侵细菌作出反应。为了消灭细菌，巨噬细胞采用多种策略，其中抗原加工和呈递给T细胞、吞噬作用、趋化作用以及不同的杀菌机制被认为是主要武器。
