Kraus T, Drexler H, Weber A, Raithel H J
Institute for Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Germany.
Isr J Med Sci. 1995 Sep;31(9):540-8.
Controversy exists as to whether occupational asbestos dust exposure is responsible, or at least partially responsible, for the development of laryngeal carcinoma. The aim of this study is to present the current scientific knowledge on this subject based on a comprehensive literature research and to critically review the epidemiological investigations published. The results of 31 cohort studies and 24 case-control studies, and the conclusions in 11 more recent reviews are contradictory. In most studies there was no statistically significant indication of a casual relationship. It is noteworthy that an increased risk of laryngeal carcinoma among persons exposed to asbestos dust was observed mostly in older studies in which smoking habits and/or alcohol consumption as the most important nonoccupational risk factors were usually not taken into account. In addition, since most of the calculated positive associations are very weak, no reliable conclusion can be reached. While there may be a causal relationship between occupational exposure to asbestos dust and the occurrence of laryngeal carcinoma, this cannot be regarded as certain on the basis of the evidence reviewed.
职业性接触石棉粉尘是否是导致喉癌的原因，或者至少是部分原因，目前仍存在争议。本研究的目的是基于全面的文献研究，呈现关于该主题的当前科学知识，并对已发表的流行病学调查进行批判性综述。31项队列研究和24项病例对照研究的结果，以及11篇近期综述中的结论相互矛盾。在大多数研究中，没有统计学上显著的证据表明存在因果关系。值得注意的是，接触石棉粉尘人群患喉癌风险增加的情况大多出现在早期研究中，这些研究通常没有考虑吸烟习惯和/或饮酒这两个最重要的非职业性风险因素。此外，由于大多数计算得出的正相关关系非常微弱，无法得出可靠的结论。虽然职业性接触石棉粉尘与喉癌的发生之间可能存在因果关系，但基于所审查的证据，这一点尚不能确定。
