参与肿瘤形成、止血和伤口愈合的细胞黏附及调节分子。

Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing.

作者信息

Van Waes C

机构信息

Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Head Neck. 1995 Mar-Apr;17(2):140-7. doi: 10.1002/hed.2880170212.

DOI:10.1002/hed.2880170212

PMID:7558812

Abstract

BACKGROUND

Dynamic changes in cell adhesion and migration are fundamental properties of the cells that are important in hemostasis, vascularization, and wound repair. Changes in cell adhesion and migration are very important in the formation of tumors, and invasion and metastasis by neoplasms.

METHODS

Using immunolocalization and immunopurification techniques, expression of integrin molecules involved in cell adhesion has been characterized during tumor development and wound healing. The ability of cytokines to regulate expression and antibody and peptide inhibitors to inhibit function of integrins has been explored to better understand the role of integrins in pathogenesis.

RESULTS

Increased suprabasilar expression of the integrins alpha 6 beta 4, alpha 2 beta 1, and alpha 3 beta 1 accompanies development of squamous cell neoplasms of the head and neck. Integrin alpha II beta 3 is an integrin receptor which is important in platelet aggregation in hemostasis and formation of tumor metastases. Increased expression of integrin alpha v beta 3 has been identified in angiogenesis in response to growth factors and tumor angiogenic factors. Cytokine TGF-beta and arachadonic acid metabolite 12(S)-HETE are important signals in regulation of integrins and affect cell aggregation and migration in these processes. Ligands and inhibitors for some of these receptors have been identified which will be useful in determining their role during tumor development and progression.

CONCLUSION

Recent advances in understanding the functions of the integrin cell adhesion molecules may soon add new diagnostic methods and therapies to the armamentarium of the head and neck oncologic, microvascular, plastic, and reconstructive surgeon. Therapies directed at controlling integrin cell-adhesion molecule expression and function are being explored to improve scar formation, bone synthesis, inhibition of vascular occlusion, and inhibition of tumor invasion and metastasis.

摘要

背景

细胞黏附和迁移的动态变化是细胞的基本特性，在止血、血管形成和伤口修复中具有重要意义。细胞黏附和迁移的变化在肿瘤形成以及肿瘤的侵袭和转移过程中也非常重要。

方法

运用免疫定位和免疫纯化技术，在肿瘤发展和伤口愈合过程中对参与细胞黏附的整合素分子表达进行了表征。为了更好地理解整合素在发病机制中的作用，研究了细胞因子调节整合素表达的能力以及抗体和肽抑制剂抑制整合素功能的能力。

结果

整合素α6β4、α2β1和α3β1在基底上层的表达增加伴随着头颈部鳞状细胞肿瘤的发展。整合素αIIβ3是一种整合素受体，在止血过程中的血小板聚集和肿瘤转移形成中起重要作用。已发现在对生长因子和肿瘤血管生成因子的反应中，整合素αvβ3在血管生成中的表达增加。细胞因子转化生长因子-β和花生四烯酸代谢产物12(S)-羟基二十碳四烯酸是调节整合素的重要信号，并在这些过程中影响细胞聚集和迁移。已鉴定出其中一些受体的配体和抑制剂，这将有助于确定它们在肿瘤发展和进展过程中的作用。