Lloyd R D, Angus W, Taylor G N, Bruenger F W, Miller S C
University of Utah School of Medicine, Salt Lake City 84112, USA.
Health Phys. 1995 Oct;69(4):530-7. doi: 10.1097/00004032-199510000-00012.
Individual records of soft tissue tumor occurrence (lifetime incidence) among 236 beagles injected with 239Pu citrate as young adults and 131 comparable control beagles given no radioactivity enabled us to analyze the possible effects on soft tissue tumor induction resulting from internal exposure to 239Pu. A significant trend was identified in the proportion of animals having malignant liver tumors with increasing radiation dose from 239Pu. There was also a significant difference in the relative numbers of both malignant liver tumors (3.2 expected, 22 observed) and benign liver tumors (18.1 expected, 66 observed). Malignant tumors of the mouth, pancreas, and skin were more frequent among controls than among the dogs given 239Pu as were all tumors (malignant plus benign) of the mouth, pancreas, testis, and vagina. For all other tumor sites or types, there was no significant difference for both malignant and all (malignant plus benign) tumors. Mammary tumor occurrence appeared not to be associated with 239Pu incorporation. We conclude that the only soft-tissue neoplasia induced by the intake of 239Pu directly into blood is probably a liver tumor.
对236只成年时注射柠檬酸钚-239的比格犬以及131只未接触放射性物质的对照比格犬的软组织肿瘤发生情况（终生发病率）进行的个体记录，使我们能够分析内部接触钚-239对软组织肿瘤诱发可能产生的影响。在患有恶性肝肿瘤的动物比例方面，随着钚-239辐射剂量的增加呈现出显著趋势。恶性肝肿瘤（预期3.2例，观察到22例）和良性肝肿瘤（预期18.1例，观察到66例）的相对数量也存在显著差异。在对照组中，口腔、胰腺和皮肤的恶性肿瘤比注射钚-239的犬更为常见，口腔、胰腺、睾丸和阴道的所有肿瘤（恶性加良性）也是如此。对于所有其他肿瘤部位或类型，恶性肿瘤和所有肿瘤（恶性加良性）均无显著差异。乳腺肿瘤的发生似乎与钚-239的摄入无关。我们得出结论，直接摄入钚-239至血液中所诱发的唯一软组织肿瘤可能是肝肿瘤。
