TCRBV12 genes are polymorphic but the protein products encoded by each gene are conserved.
作者信息
Deulofeut H, Wilderson J L, Barron K S, Robinson M A
机构信息
Laboratory of Immunogenetics, Twinbrook II Facility, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
出版信息
Hum Immunol. 1995 Jul;43(3):227-30. doi: 10.1016/0198-8859(94)00152-g.
PMID:7558940
Abstract
The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are conservative. Although allelic variants exist for each of the three BV12 genes, only one protein product is encoded by each gene.
摘要
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