氨苄西林、阿莫西林、阿莫西林/克拉维酸和头孢噻肟对189株青霉素敏感和耐药肺炎球菌的比较活性
Comparative activity of ampicillin, amoxycillin, amoxycillin/clavulanate and cefotaxime against 189 penicillin-susceptible and -resistant pneumococci.
作者信息
Pankuch G A, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology, Clinical Microbiology, Hershey Medical Center, Hershey, PA 17033, USA.
出版信息
J Antimicrob Chemother. 1995 Jun;35(6):883-8. doi: 10.1093/jac/35.6.883.
Agar dilution and E-test MICs of penicillin G, ampicillin, amoxycillin, amoxycillin/clavulanate and cefotaxime were determined against 189 pneumococci. Addition of clavulanate did not influence amoxycillin MICs, MIC50/MIC90 (mg/L) for penicillin G, ampicillin, amoxycillin and cefotaxime were: Penicillin susceptible strains (62): 0.03/0.03; 0.03/0.06; 0.015/0.03; 0.015/0.06. Penicillin intermediate strains (69): 0.25/1.0; 0.25/4.0; 0.125/1.0; 0.125/1.0. Penicillin resistant strains (58): 2.0/4.0; 4.0/4.0; 1.0/2.0; 1.0/2.0. E-test MICs correlated well with those obtained by agar dilution.
采用琼脂稀释法和E试验测定了189株肺炎球菌对青霉素G、氨苄西林、阿莫西林、阿莫西林/克拉维酸和头孢噻肟的最低抑菌浓度（MIC）。添加克拉维酸不影响阿莫西林的MIC，青霉素G、氨苄西林、阿莫西林和头孢噻肟的MIC50/MIC90（mg/L）分别为：青霉素敏感菌株（62株）：0.03/0.03；0.03/0.06；0.015/0.03；0.015/0.06。青霉素中介菌株（69株）：0.25/1.0；0.25/4.0；0.125/1.0；0.125/1.0。青霉素耐药菌株（58株）：2.0/4.0；4.0/4.0；1.0/2.0；1.0/2.0。E试验所得MIC与琼脂稀释法结果高度相关。
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