Tordjman S, Anderson G M, McBride P A, Hertzig M E, Snow M E, Hall L M, Ferrari P, Cohen D J
Department of Psychiatry, Université de Paris-Sud, France.
J Autism Dev Disord. 1995 Jun;25(3):295-304. doi: 10.1007/BF02179290.
Plasma levels of testosterone and the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) were measured in male autistic subjects (31 prepubertal, 8 postpubertal), mentally retarded/cognitively impaired subjects (MR, 12 prepubertal), and normal control subjects (NC, 10 prepubertal, 11 postpubertal). Mean levels of plasma testosterone were similar in the postpubertal autistic (4.54 +/- 1.12 ng/ml) and postpubertal NC (5.02 +/- 1.87 ng/ml) groups. Plasma DHEA-S levels in postpubertal autistic (2170 +/- 1020 ng/ml) and postpubertal NC (1850 +/- 777 ng/ml) groups also were not significantly different. Similarly, no significant group differences were seen for testosterone or DHEA-S in the prepubertal autistic, MR, or NC individuals, although prepubertal MR individuals with cerebral palsy did have increased plasma DHEA-S levels compared to age-matched MR or NC individuals. Significant negative correlations were found between testosterone and whole blood serotonin (5-HT) levels in the combined (all subjects, all ages) groups and in the autistic group, suggesting that the effect of puberty on whole blood 5-HT may deserve further study. Data indicate that altered secretion of the androgens is not a common feature of autism. However, abnormalities of adrenal androgen secretion may be present in individuals with cerebral palsy.
对男性自闭症患者（31名青春期前，8名青春期后）、智力迟钝/认知障碍患者（MR，12名青春期前）和正常对照者（NC，10名青春期前，11名青春期后）测量了血浆睾酮和肾上腺雄激素硫酸脱氢表雄酮（DHEA-S）水平。青春期后自闭症组（4.54±1.12 ng/ml）和青春期后NC组（5.02±1.87 ng/ml）的血浆睾酮平均水平相似。青春期后自闭症组（2170±1020 ng/ml）和青春期后NC组（1850±777 ng/ml）的血浆DHEA-S水平也无显著差异。同样，青春期前自闭症、MR或NC个体的睾酮或DHEA-S水平也无显著组间差异，不过与年龄匹配的MR或NC个体相比，患有脑瘫的青春期前MR个体的血浆DHEA-S水平确实有所升高。在合并组（所有受试者，所有年龄）和自闭症组中，发现睾酮与全血5-羟色胺（5-HT）水平之间存在显著负相关，这表明青春期对全血5-HT的影响可能值得进一步研究。数据表明，雄激素分泌改变并非自闭症的常见特征。然而，患有脑瘫的个体可能存在肾上腺雄激素分泌异常。
